Mature b cell

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Utbildning Expandera Utbildning Minimera Utbildning. Activation of B cells with CD40L or CpG measures the functions of different B cell subsets and identifies specific defects in B cells from patients with immunodeficiency. This B cell phenotype was found to be associated with an increasing age. Our aim is to better understand the molecular and cellular mechanisms underlying the development of disease. When the cells leave these structures, they differentiate into memory B cells MBC or antibody-secreting plasma cells. However, their role in regulating B cell homeostasis has remained unknown.

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Eva Sjögren Nilsson Sidan uppdaterades:

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B cells in health and disease

This B cell phenotype was found to be associated with an increasing age. These diseases are complex, including gender, genetic and environmental factors. Om institutionen Expandera Om institutionen Minimera Om institutionen. Our research translational; our observations in mouse models are translated to healthy individuals and patients, and vice versa. In secondary lymphoid organs, the interaction between CD47 and SIRPα has been shown to be important in the homeostasis of T lymphocytes and CD8 - dendritic cells, but a possible role in regulating B cell homeostasis remain unidentified.

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