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Although drugs like rapamycin, chloroquine, hydroxychloroquine, and others act as autophagy modulators, they were not originally developed for this purpose. In general, carboxylic acids have low potency but only target class I enzymes; hydroxamic acids have the highest potency but the lowest isoform selectivity; ortho -amino anilides fall into an intermediate category with class I isoform selectivity and moderate potency. In addition, Zou et al. As it interacts with a number of proteins in different intracellular signaling pathways, p62 plays an important role at the crossroads of autophagy, apoptosis, and cancer [ — ]. Since autophagy plays a dual role in the pathophysiology of malignant liver diseases, it is important to define whether a specific cancer type requires autophagy induction or inhibition to propagate.

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Bhalla, in Advances in Cancer Research4.

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Molecular Therapy of Breast Cancer

Kanske ger jag mig in på det när läst och fått mer kunskap. Clinical trials involving autophagy modulation in cancers have been designed to assess the effect of autophagy inhibition in combination with other conventional therapies. Altogether, these studies indicate that selective autophagy represents a large array of distinct but overlapping pathways to dispose of damaged or potentially toxic cellular content. Please check your Internet connection and reload this page. A phase I dose-escalation study with 27 patients to evaluate the maximum tolerated dose and safety of combining temsirolimus rapamycin analog with HCQ was also performed by Rangwala et al.

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